Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83566
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
47900±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83566
Synonyms:
(3aS,6aS)-3-(Quinoline-2-carbonyl)-5-(3-trifluoromethyl-phenyl)-3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione | (3aS,6aS)-3-(quinoline-2-carbonyl)-5-[3-(trifluoromethyl)phenyl]-3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione | (3aS,6aS)-3-[oxo(2-quinolinyl)methyl]-5-[3-(trifluoromethyl)phenyl]-3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione | (3aS,6aS)-3-quinaldoyl-5-[3-(trifluoromethyl)phenyl]-3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-quinone | (3aS,6aS)-3-quinolin-2-ylcarbonyl-5-[3-(trifluoromethyl)phenyl]-3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione | MLS000589495 | SMR000212847 | cid_12005771
Type:
Small organic molecule
Emp. Form.:
C22H13F3N4O3
Mol. Mass.:
438.3588
SMILES:
Oc1n(-c2cccc(c2)C(F)(F)F)c(=O)c2c([nH][nH]c12)C(=O)c1ccc2ccccc2n1
Structure:
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