Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83578
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83578
Synonyms:
(E)-2-cyano-3-(4-methoxyphenyl)-2-propenoic acid [2-(2,6-diethylanilino)-2-oxoethyl] ester | (E)-2-cyano-3-(4-methoxyphenyl)acrylic acid [2-(2,6-diethylanilino)-2-keto-ethyl] ester | MLS000389966 | SMR000256240 | [2-(2,6-diethylanilino)-2-oxoethyl] (E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoate | [2-[(2,6-diethylphenyl)amino]-2-oxidanylidene-ethyl] (E)-2-cyano-3-(4-methoxyphenyl)prop-2-enoate | cid_2371823
Type:
Small organic molecule
Emp. Form.:
C23H24N2O4
Mol. Mass.:
392.4477
SMILES:
CCc1cccc(CC)c1NC(=O)COC(=O)C(=C\c1ccc(OC)cc1)\C#N
Structure:
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