Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83585
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
10700±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83585
Synonyms:
(4Z)-4-[4-(dimethylamino)benzylidene]-1-(2-furfuryl)-5-keto-2-methyl-2-pyrroline-3-carboxylic acid methyl ester | (4Z)-4-[[4-(dimethylamino)phenyl]methylidene]-1-(2-furanylmethyl)-2-methyl-5-oxo-3-pyrrolecarboxylic acid methyl ester | MLS000666160 | SMR000271460 | cid_1746835 | methyl (4Z)-4-[[4-(dimethylamino)phenyl]methylidene]-1-(furan-2-ylmethyl)-2-methyl-5-oxidanylidene-pyrrole-3-carboxylate | methyl (4Z)-4-[[4-(dimethylamino)phenyl]methylidene]-1-(furan-2-ylmethyl)-2-methyl-5-oxopyrrole-3-carboxylate | methyl 4-[4-(dimethylamino)benzylidene]-1-(2-furylmethyl)-2-methyl-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C21H22N2O4
Mol. Mass.:
366.4104
SMILES:
COC(=O)C1=C(C)N(Cc2ccco2)C(=O)\C1=C/c1ccc(cc1)N(C)C |c:4|
Structure:
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