Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM51116
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM51116
Synonyms:
(5E)-1-(3-bromophenyl)-5-[(1,2,5-trimethyl-3-pyrrolyl)methylidene]-1,3-diazinane-2,4,6-trione | (5E)-1-(3-bromophenyl)-5-[(1,2,5-trimethylpyrrol-3-yl)methylene]barbituric acid | (5E)-1-(3-bromophenyl)-5-[(1,2,5-trimethylpyrrol-3-yl)methylidene]-1,3-diazinane-2,4,6-trione | 1-(3-bromophenyl)-5-[(1,2,5-trimethyl-1H-pyrrol-3-yl)methylene]-2,4,6(1H,3H,5H)-pyrimidinetrione | MLS000666676 | SMR000268599 | cid_1349648
Type:
Small organic molecule
Emp. Form.:
C18H16BrN3O3
Mol. Mass.:
402.242
SMILES:
Cc1cc(C=C2C(=O)NC(=O)N(C2=O)c2cccc(Br)c2)c(C)n1C |w:4.3|
Structure:
Search PDB for entries with ligand similarity: