Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83600
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
7120±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83600
Synonyms:
2-[2-[(4-fluorophenyl)methylidene]hydrazinyl]-1H-quinazolin-4-one | 2-[N'-(4-fluorobenzylidene)hydrazino]-1H-quinazolin-4-one | 4-fluorobenzaldehyde (4-oxo-3,4-dihydro-2-quinazolinyl)hydrazone | MLS000700887 | SMR000230629 | cid_5227289
Type:
Small organic molecule
Emp. Form.:
C15H11FN4O
Mol. Mass.:
282.2724
SMILES:
Fc1ccc(CN=Nc2nc3ccccc3c(=O)[nH]2)cc1 |w:7.7|
Structure:
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