Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83614
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
59200±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83614
Synonyms:
MLS001032916 | SMR000363438 | [2-cyano-2-[3-(3-ethyl-1-pyridin-1-iumyl)-2-quinoxalinyl]ethenylidene]azanide | [2-cyano-2-[3-(3-ethylpyridin-1-ium-1-yl)quinoxalin-2-yl]ethenylidene]azanide | cid_2312618
Type:
Small organic molecule
Emp. Form.:
C18H13N5
Mol. Mass.:
299.3293
SMILES:
CCc1ccc[n+](c1)-c1nc2ccccc2nc1[C-](C#N)C#N
Structure:
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