Target
Endoribonuclease toxin MazF
Ligand
BDBM52930
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM52930
Synonyms:
(E)-2-benzoyl-3-[5-[2-methyl-5-(trifluoromethyl)-3-pyrazolyl]-2-thiophenyl]-2-propenenitrile | (E)-2-benzoyl-3-[5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-2-thienyl]acrylonitrile | (E)-2-benzoyl-3-[5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophen-2-yl]prop-2-enenitrile | (E)-3-[5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]thiophen-2-yl]-2-(phenylcarbonyl)prop-2-enenitrile | 2-benzoyl-3-{5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-2-thienyl}acrylonitrile | MLS000860715 | SMR000459499 | cid_5715773
Type:
Small organic molecule
Emp. Form.:
C19H12F3N3OS
Mol. Mass.:
387.378
SMILES:
Cn1nc(cc1-c1ccc(\C=C(/C#N)C(=O)c2ccccc2)s1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: