Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83651
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83651
Synonyms:
(7-methyl-2-oxidanylidene-chromen-4-yl)methyl 2-bromanyl-5-methoxy-benzoate | (7-methyl-2-oxochromen-4-yl)methyl 2-bromo-5-methoxybenzoate | 2-bromo-5-methoxy-benzoic acid (2-keto-7-methyl-chromen-4-yl)methyl ester | 2-bromo-5-methoxybenzoic acid (7-methyl-2-oxo-1-benzopyran-4-yl)methyl ester | MLS001176537 | SMR000595456 | cid_2639976
Type:
Small organic molecule
Emp. Form.:
C19H15BrO5
Mol. Mass.:
403.223
SMILES:
COc1ccc(Br)c(c1)C(=O)OCc1cc(=O)oc2cc(C)ccc12
Structure:
Search PDB for entries with ligand similarity: