Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83692
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
3830±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83692
Synonyms:
MLS002425460 | SMR001371386 | cid_44142831
Type:
Small organic molecule
Emp. Form.:
C29H27FN2O3
Mol. Mass.:
470.5347
SMILES:
[H][C@]12COc3ccc(C)cc3[C@]1([H])N1C(=O)CN(Cc3ccc(F)cc3)C(=O)[C@@]1(C)[C@H]2c1ccccc1
Structure:
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