Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM41489
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
55900±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM41489
Synonyms:
(4Z)-2-(4-fluorophenyl)-4-[(2-methyl-1H-indol-3-yl)methylene]-2-oxazolin-5-one | (4Z)-2-(4-fluorophenyl)-4-[(2-methyl-1H-indol-3-yl)methylidene]-1,3-oxazol-5-one | (4Z)-2-(4-fluorophenyl)-4-[(2-methyl-1H-indol-3-yl)methylidene]-5-oxazolone | 2-(4-fluorophenyl)-4-[(2-methyl-1H-indol-3-yl)methylene]-1,3-oxazol-5(4H)-one | MLS000531355 | SMR000136333 | cid_5646019
Type:
Small organic molecule
Emp. Form.:
C19H13FN2O2
Mol. Mass.:
320.3171
SMILES:
Cc1[nH]c2ccccc2c1\C=C1/N=C(OC1=O)c1ccc(F)cc1 |c:14|
Structure:
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