Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM52262
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM52262
Synonyms:
4-[(4-hydroxyanilino)methyl]-1(2H)-phthalazinone | 4-[(4-hydroxyanilino)methyl]-2H-phthalazin-1-one | 4-[[(4-hydroxyphenyl)amino]methyl]-2H-phthalazin-1-one | MLS000594338 | SMR000126518 | cid_1482943
Type:
Small organic molecule
Emp. Form.:
C15H13N3O2
Mol. Mass.:
267.2826
SMILES:
Oc1ccc(NCc2n[nH]c(=O)c3ccccc23)cc1
Structure:
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