Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM52390
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM52390
Synonyms:
6-keto-N,1-diphenyl-4-(trifluoromethyl)pyridazine-3-carboxamide | 6-oxidanylidene-N,1-diphenyl-4-(trifluoromethyl)pyridazine-3-carboxamide | 6-oxo-N,1-diphenyl-4-(trifluoromethyl)-1,6-dihydro-3-pyridazinecarboxamide | 6-oxo-N,1-diphenyl-4-(trifluoromethyl)-3-pyridazinecarboxamide | 6-oxo-N,1-diphenyl-4-(trifluoromethyl)pyridazine-3-carboxamide | MLS000327050 | SMR000179541 | cid_1489974
Type:
Small organic molecule
Emp. Form.:
C18H12F3N3O2
Mol. Mass.:
359.302
SMILES:
FC(F)(F)c1cc(=O)n(nc1C(=O)Nc1ccccc1)-c1ccccc1
Structure:
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