Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM50958
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
6290±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM50958
Synonyms:
(E)-3-(4-ethoxy-2-nitro-anilino)-1-(4-methoxyphenyl)prop-2-en-1-one | (E)-3-(4-ethoxy-2-nitroanilino)-1-(4-methoxyphenyl)-2-propen-1-one | (E)-3-(4-ethoxy-2-nitroanilino)-1-(4-methoxyphenyl)prop-2-en-1-one | (E)-3-[(4-ethoxy-2-nitro-phenyl)amino]-1-(4-methoxyphenyl)prop-2-en-1-one | 3-[(4-ethoxy-2-nitrophenyl)amino]-1-(4-methoxyphenyl)-2-propen-1-one | MLS000578662 | SMR000186155 | cid_5334510
Type:
Small organic molecule
Emp. Form.:
C18H18N2O5
Mol. Mass.:
342.3459
SMILES:
CCOc1ccc(N=CCC(=O)c2ccc(OC)cc2)c(c1)[N+]([O-])=O |w:7.6|
Structure:
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