Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83596
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
9490±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83596
Synonyms:
(5Z)-1-cyclohexyl-5-[(E)-3-phenylazanylprop-2-enylidene]-1,3-diazinane-2,4,6-trione | (5Z)-5-[(E)-3-anilinoprop-2-enylidene]-1-cyclohexyl-1,3-diazinane-2,4,6-trione | (5Z)-5-[(E)-3-anilinoprop-2-enylidene]-1-cyclohexyl-barbituric acid | 1-Cyclohexyl-5-[(E)-3-phenylamino-prop-2-en-(Z)-ylidene]-pyrimidine-2,4,6-trione | MLS000589654 | SMR000219487 | cid_5554345
Type:
Small organic molecule
Emp. Form.:
C19H21N3O3
Mol. Mass.:
339.3883
SMILES:
O=C1NC(=O)C(=CCC=Nc2ccccc2)C(=O)N1C1CCCCC1 |w:9.9,6.6|
Structure:
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