Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83655
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
39200±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83655
Synonyms:
(E)-2-cyano-3-[4-(methylamino)-3-nitro-phenyl]-N-(2-pyridyl)acrylamide | (E)-2-cyano-3-[4-(methylamino)-3-nitro-phenyl]-N-pyridin-2-yl-prop-2-enamide | (E)-2-cyano-3-[4-(methylamino)-3-nitrophenyl]-N-(2-pyridinyl)-2-propenamide | (E)-2-cyano-3-[4-(methylamino)-3-nitrophenyl]-N-pyridin-2-ylprop-2-enamide | MLS001171340 | SMR000589564 | cid_6311448
Type:
Small organic molecule
Emp. Form.:
C16H13N5O3
Mol. Mass.:
323.3061
SMILES:
CNc1ccc(\C=C(/C#N)C(=O)Nc2ccccn2)cc1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: