Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83660
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
58400±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83660
Synonyms:
(2-methoxy-5-methyl-phenyl)-[(5E)-5-(5-methoxy-3-nitro-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)-4-phenyl-1,3,4-thiadiazolidin-2-ylidene]azanium;chloride | (2-methoxy-5-methylphenyl)-[(5E)-5-(5-methoxy-3-nitro-6-oxo-1-cyclohexa-2,4-dienylidene)-4-phenyl-1,3,4-thiadiazolidin-2-ylidene]ammonium;chloride | (2-methoxy-5-methylphenyl)-[(5E)-5-(5-methoxy-3-nitro-6-oxocyclohexa-2,4-dien-1-ylidene)-4-phenyl-1,3,4-thiadiazolidin-2-ylidene]azanium;chloride | MLS000948483 | SMR000526899 | [(5E)-5-(6-keto-5-methoxy-3-nitro-cyclohexa-2,4-dien-1-ylidene)-4-phenyl-1,3,4-thiadiazolidin-2-ylidene]-(2-methoxy-5-methyl-phenyl)ammonium;chloride | cid_24789728
Type:
Small organic molecule
Emp. Form.:
C23H21N4O5S
Mol. Mass.:
465.501
SMILES:
COc1ccc(C)cc1Nc1[nH+][n+](c(s1)-[c-]1cc(cc(OC)c1=O)[N+]([O-])=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: