Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM81278
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM81278
Synonyms:
4-(4-methylphenyl)sulfinyl-7-nitro-2,1,3-benzoxadiazole | 4-nitro-7-(p-tolylsulfinyl)benzofurazan | MLS003115156 | SMR001830739 | US20230364057, Compound 222 | cid_313614
Type:
Small organic molecule
Emp. Form.:
C13H9N3O4S
Mol. Mass.:
303.293
SMILES:
Cc1ccc(cc1)S(=O)c1ccc([N+]([O-])=O)c2nonc12
Structure:
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