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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83748
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59647±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83748
Synonyms:
1-(1-tert-butyl-1,2,3,4-tetrazol-5-yl)-N-(furan-2-ylmethyl)-N-(phenylmethyl)-1-pyridin-3-yl-methanamine | 1-(1-tert-butyl-5-tetrazolyl)-N-(2-furanylmethyl)-N-(phenylmethyl)-1-(3-pyridinyl)methanamine | Benzyl-[(1-tert-butyl-1H-tetrazol-5-yl)-pyridin-3-yl-methyl]-furan-2-ylmethyl-amine | MLS000528003 | N-benzyl-1-(1-tert-butyltetrazol-5-yl)-N-(furan-2-ylmethyl)-1-pyridin-3-ylmethanamine | SMR000120577 | benzyl-[(1-tert-butyltetrazol-5-yl)-(3-pyridyl)methyl]-(2-furfuryl)amine | cid_3229317
Type:
Small organic molecule
Emp. Form.:
C23H26N6O
Mol. Mass.:
402.4921
SMILES:
CC(C)(C)n1nnnc1C(N(Cc1ccco1)Cc1ccccc1)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: