Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM61665
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59631±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM61665
Synonyms:
3-(4-chlorophenyl)-1-(4-methylanilino)pyrrole-2,5-dione | 3-(4-chlorophenyl)-1-(4-toluidino)-1H-pyrrole-2,5-dione | 3-(4-chlorophenyl)-1-(p-toluidino)-3-pyrroline-2,5-quinone | 3-(4-chlorophenyl)-1-[(4-methylphenyl)amino]pyrrole-2,5-dione | MLS000540408 | SMR000125666 | cid_5094315
Type:
Small organic molecule
Emp. Form.:
C17H13ClN2O2
Mol. Mass.:
312.75
SMILES:
Cc1ccc(NN2C(=O)C=C(C2=O)c2ccc(Cl)cc2)cc1 |c:9|
Structure:
Search PDB for entries with ligand similarity: