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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83759
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>2207±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83759
Synonyms:
(2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-yl)amine | 2,4,9-Trimethyl-benzo[b][1,8]naphthyridin-5-ylamine | 2,4,9-trimethyl-5-benzo[b][1,8]naphthyridinamine | 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine | MLS000552981 | SMR000178181 | cid_698490
Type:
Small organic molecule
Emp. Form.:
C15H15N3
Mol. Mass.:
237.2997
SMILES:
Cc1cc(C)c2c(N)c3cccc(C)c3nc2n1
Structure:
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