Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83778
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59652±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83778
Synonyms:
MLS000392284 | N-[5-[4-(difluoromethylthio)benzyl]thiazol-2-yl]-4-methyl-benzamide | N-[5-[[4-(difluoromethylsulfanyl)phenyl]methyl]-1,3-thiazol-2-yl]-4-methylbenzamide | N-[5-[[4-(difluoromethylthio)phenyl]methyl]-2-thiazolyl]-4-methylbenzamide | N-[5-[[4-[bis(fluoranyl)methylsulfanyl]phenyl]methyl]-1,3-thiazol-2-yl]-4-methyl-benzamide | SMR000261226 | cid_1527277
Type:
Small organic molecule
Emp. Form.:
C19H16F2N2OS2
Mol. Mass.:
390.47
SMILES:
Cc1ccc(cc1)C(=O)Nc1ncc(Cc2ccc(SC(F)F)cc2)s1
Structure:
Search PDB for entries with ligand similarity: