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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83792
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59610±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83792
Synonyms:
(2-aminophenyl)-[3-(trifluoromethyl)phenyl]amine | 2-N-[3-(trifluoromethyl)phenyl]benzene-1,2-diamine | MLS000755670 | N2-[3-(trifluoromethyl)phenyl]benzene-1,2-diamine | N~1~-[3-(trifluoromethyl)phenyl]-1,2-benzenediamine | SMR000337335 | cid_3729763
Type:
Small organic molecule
Emp. Form.:
C13H11F3N2
Mol. Mass.:
252.235
SMILES:
Nc1ccccc1Nc1cccc(c1)C(F)(F)F
Structure:
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