Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83796
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59654±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83796
Synonyms:
3-[(3,4-dimethoxyphenyl)methyl]-N-[2-(4-fluorophenyl)ethyl]-7-oxidanylidene-2H-[1,2,3]triazolo[4,5-d]pyrimidine-5-carboxamide | 3-[(3,4-dimethoxyphenyl)methyl]-N-[2-(4-fluorophenyl)ethyl]-7-oxo-2H-triazolo[4,5-d]pyrimidine-5-carboxamide | MLS000878215 | N-[2-(4-fluorophenyl)ethyl]-7-keto-3-veratryl-2H-triazolo[4,5-d]pyrimidine-5-carboxamide | SMR000092595 | cid_6324549
Type:
Small organic molecule
Emp. Form.:
C22H21FN6O4
Mol. Mass.:
452.4383
SMILES:
COc1ccc(Cn2nnc3c2nc([nH]c3=O)C(=O)NCCc2ccc(F)cc2)cc1OC
Structure:
Search PDB for entries with ligand similarity: