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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83865
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59629±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83865
Synonyms:
4-(1-amino-3-phenylpropyl)-N-(6-methoxy-2-pyridinyl)-2-thiazolamine | 4-(1-amino-3-phenylpropyl)-N-(6-methoxypyridin-2-yl)-1,3-thiazol-2-amine | 4-(1-azanyl-3-phenyl-propyl)-N-(6-methoxypyridin-2-yl)-1,3-thiazol-2-amine | MLS003123735 | SMR001291784 | [4-(1-amino-3-phenyl-propyl)thiazol-2-yl]-(6-methoxy-2-pyridyl)amine | cid_49778365
Type:
Small organic molecule
Emp. Form.:
C18H20N4OS
Mol. Mass.:
340.443
SMILES:
COc1cccc(Nc2nc(cs2)C(N)CCc2ccccc2)n1
Structure:
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