Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM83919
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
2970±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM83919
Synonyms:
3-nitro-4-{[2-(4-methoxyphenoxy)ethyl]amino}-2H-chromen-2-one | 4-[2-(4-methoxyphenoxy)ethylamino]-3-nitro-1-benzopyran-2-one | 4-[2-(4-methoxyphenoxy)ethylamino]-3-nitro-chromen-2-one | 4-[2-(4-methoxyphenoxy)ethylamino]-3-nitro-coumarin | 4-[2-(4-methoxyphenoxy)ethylamino]-3-nitrochromen-2-one | MLS000705992 | SMR000225558 | cid_2832347
Type:
Small organic molecule
Emp. Form.:
C18H16N2O6
Mol. Mass.:
356.3294
SMILES:
COc1ccc(OCCNc2c([N+]([O-])=O)c(=O)oc3ccccc23)cc1
Structure:
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