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Target
Cysteine protease ATG4B
Ligand
BDBM42498
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B Set 2
IC50
25300±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B Set 2 PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM42498
Synonyms:
MLS000520555 | N-[2-[4-(2,3-dimethylphenyl)-1-piperazinyl]ethyl]-2-[2-[(2-methylphenyl)-oxomethyl]-1-pyrrolyl]acetamide | N-[2-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethyl]-2-[2-(2-methylbenzoyl)pyrrol-1-yl]acetamide | N-[2-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethyl]-2-[2-(2-methylphenyl)carbonylpyrrol-1-yl]ethanamide | N-[2-[4-(2,3-dimethylphenyl)piperazino]ethyl]-2-(2-o-toluoylpyrrol-1-yl)acetamide | SMR000130966 | cid_9550576
Type:
Small organic molecule
Emp. Form.:
C28H34N4O2
Mol. Mass.:
458.5952
SMILES:
Cc1cccc(N2CCN(CCNC(=O)Cn3cccc3C(=O)c3ccccc3C)CC2)c1C
Structure:
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