Reaction Details Report a problem with these data
Target
Cysteine protease ATG4B
Ligand
BDBM84012
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B Set 2
IC50
>80000±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B Set 2 PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM84012
Synonyms:
3-(2,6-dichlorophenyl)-N-[3-(trifluoromethyl)benzyl]-2-isoxazoline-5-carboxamide | 3-(2,6-dichlorophenyl)-N-[[3-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1,2-oxazole-5-carboxamide | 3-(2,6-dichlorophenyl)-N-[[3-(trifluoromethyl)phenyl]methyl]-4,5-dihydroisoxazole-5-carboxamide | 3-[2,6-bis(chloranyl)phenyl]-N-[[3-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1,2-oxazole-5-carboxamide | MLS000561832 | SMR000155963 | cid_11958503
Type:
Small organic molecule
Emp. Form.:
C18H13Cl2F3N2O2
Mol. Mass.:
417.209
SMILES:
FC(F)(F)c1cccc(CNC(=O)C2CC(=NO2)c2c(Cl)cccc2Cl)c1 |c:15|
Structure:
Search PDB for entries with ligand similarity: