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Target
Apoptotic protease-activating factor 1
Ligand
BDBM71433
Substrate
n/a
Meas. Tech.
Dose Response validation of Activators of Apaf-1 using a Fluorescent Interference Counterscreen assay
EC50
>100000±0 nM
Citation
 PubChem, PC Dose Response validation of Activators of Apaf-1 using a Fluorescent Interference Counterscreen assay PubChem Bioassay (2011)[AID] 
Target
Name:
Apoptotic protease-activating factor 1
Synonyms:
APAF1 | APAF_HUMAN | Apoptotic peptidase activating factor 1 | KIAA0413
Type:
Enzyme Catalytic Domain
Mol. Mass.:
141834.40
Organism:
Homo sapiens (Human)
Description:
O14727
Residue:
1248
Sequence:
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
  
Inhibitor
Name:
BDBM71433
Synonyms:
(NE)-2,5-dimethyl-N-[4-oxidanylidene-3-(phenylsulfonylamino)naphthalen-1-ylidene]benzenesulfonamide | (NE)-N-[3-(benzenesulfonamido)-4-keto-1-naphthylidene]-2,5-dimethyl-benzenesulfonamide | (NE)-N-[3-(benzenesulfonamido)-4-oxo-1-naphthalenylidene]-2,5-dimethylbenzenesulfonamide | (NE)-N-[3-(benzenesulfonamido)-4-oxonaphthalen-1-ylidene]-2,5-dimethylbenzenesulfonamide | MLS000948070 | SMR000620238 | cid_24789788
Type:
Small organic molecule
Emp. Form.:
C24H20N2O5S2
Mol. Mass.:
480.556
SMILES:
Cc1ccc(C)c(c1)S(=O)(=O)\N=C1/C=C(NS(=O)(=O)c2ccccc2)C(=O)c2ccccc12 |t:14|
Structure:
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