Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83682
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
5150±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83682
Synonyms:
2-(3-Cyano-quinolin-2-ylsulfanyl)-N-(2-morpholin-4-yl-phenyl)-acetamide | 2-(3-cyanoquinolin-2-yl)sulfanyl-N-(2-morpholin-4-ylphenyl)acetamide | 2-(3-cyanoquinolin-2-yl)sulfanyl-N-(2-morpholin-4-ylphenyl)ethanamide | 2-[(3-cyano-2-quinolinyl)thio]-N-[2-(4-morpholinyl)phenyl]acetamide | 2-[(3-cyano-2-quinolyl)thio]-N-(2-morpholinophenyl)acetamide | MLS001385496 | SMR000007880 | cid_648877
Type:
Small organic molecule
Emp. Form.:
C22H20N4O2S
Mol. Mass.:
404.485
SMILES:
O=C(CSc1nc2ccccc2cc1C#N)Nc1ccccc1N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: