Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83666
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83666
Synonyms:
4-methylbenzoic acid [5-amino-1-(4-fluorophenyl)sulfonyl-3-pyrazolyl] ester | 4-methylbenzoic acid [5-amino-1-(4-fluorophenyl)sulfonyl-pyrazol-3-yl] ester | MLS000936137 | SMR000620881 | [5-amino-1-(4-fluorophenyl)sulfonylpyrazol-3-yl] 4-methylbenzoate | [5-azanyl-1-(4-fluorophenyl)sulfonyl-pyrazol-3-yl] 4-methylbenzoate | cid_4152828
Type:
Small organic molecule
Emp. Form.:
C17H14FN3O4S
Mol. Mass.:
375.374
SMILES:
Cc1ccc(cc1)C(=O)Oc1cc(N)n(n1)S(=O)(=O)c1ccc(F)cc1
Structure:
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