Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83659
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
3480±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83659
Synonyms:
3,4,5-trimethoxybenzoic acid [5-amino-1-(4-fluorophenyl)sulfonyl-3-pyrazolyl] ester | 3,4,5-trimethoxybenzoic acid [5-amino-1-(4-fluorophenyl)sulfonyl-pyrazol-3-yl] ester | MLS000936157 | SMR000620883 | [5-amino-1-(4-fluorophenyl)sulfonylpyrazol-3-yl] 3,4,5-trimethoxybenzoate | [5-azanyl-1-(4-fluorophenyl)sulfonyl-pyrazol-3-yl] 3,4,5-trimethoxybenzoate | cid_5056423
Type:
Small organic molecule
Emp. Form.:
C19H18FN3O7S
Mol. Mass.:
451.426
SMILES:
COc1cc(cc(OC)c1OC)C(=O)Oc1cc(N)n(n1)S(=O)(=O)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: