Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM61006
Substrate
n/a
Meas. Tech.
Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II
IC50
990.36±344.06 nM
Citation
PubChem, PC Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
Inhibitor
Name:
BDBM61006
Synonyms:
4-[(3,4-dichlorophenyl)carbamoyl-(2-methoxyethyl)amino]piperidine-1-carboxylic acid ethyl ester | 4-[[(3,4-dichloroanilino)-oxomethyl]-(2-methoxyethyl)amino]-1-piperidinecarboxylic acid ethyl ester | MLS000096130 | SMR000032078 | cid_3237884 | ethyl 4-[(3,4-dichlorophenyl)carbamoyl-(2-methoxyethyl)amino]piperidine-1-carboxylate | ethyl 4-[{[(3,4-dichlorophenyl)amino]carbonyl}(2-methoxyethyl)amino]piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H25Cl2N3O4
Mol. Mass.:
418.315
SMILES:
CCOC(=O)N1CCC(CC1)N(CCOC)C(=O)Nc1ccc(Cl)c(Cl)c1
Structure:
