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Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM84153
Substrate
n/a
Meas. Tech.
Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II
IC50
3112.13±347.38 nM
Citation
 PubChem, PC Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II PubChem Bioassay (2011)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM84153
Synonyms:
1-[2-keto-2-(4-methylpiperidino)ethyl]-3-piperonyl-quinazoline-2,4-quinone | 3-(1,3-benzodioxol-5-ylmethyl)-1-[2-(4-methyl-1-piperidinyl)-2-oxoethyl]quinazoline-2,4-dione | 3-(1,3-benzodioxol-5-ylmethyl)-1-[2-(4-methylpiperidin-1-yl)-2-oxidanylidene-ethyl]quinazoline-2,4-dione | 3-(1,3-benzodioxol-5-ylmethyl)-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]quinazoline-2,4(1H,3H)-dione | 3-(1,3-benzodioxol-5-ylmethyl)-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]quinazoline-2,4-dione | MLS000090609 | SMR000025213 | cid_3238464
Type:
Small organic molecule
Emp. Form.:
C24H25N3O5
Mol. Mass.:
435.4724
SMILES:
CC1CCN(CC1)C(=O)Cn1c2ccccc2c(=O)n(Cc2ccc3OCOc3c2)c1=O
Structure:
Search PDB for entries with ligand similarity: