Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM84160
Substrate
n/a
Meas. Tech.
Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II
IC50
210.48±148.02 nM
Citation
 PubChem, PC Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II PubChem Bioassay (2011)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM84160
Synonyms:
4-methyl-N-[3-methyl-1-(o-anisylcarbamoyl)butyl]cyclohexanecarboxamide | MLS000519867 | N-[1-[(2-methoxyphenyl)methylamino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methyl-cyclohexane-1-carboxamide | N-[1-[(2-methoxyphenyl)methylamino]-4-methyl-1-oxopentan-2-yl]-4-methyl-1-cyclohexanecarboxamide | N-[1-[(2-methoxyphenyl)methylamino]-4-methyl-1-oxopentan-2-yl]-4-methylcyclohexane-1-carboxamide | SMR000130282 | cid_9551525
Type:
Small organic molecule
Emp. Form.:
C22H34N2O3
Mol. Mass.:
374.517
SMILES:
COc1ccccc1CNC(=O)C(CC(C)C)NC(=O)C1CCC(C)CC1 |(13.75,5.78,;12.42,5.01,;12.42,3.47,;13.75,2.7,;13.75,1.16,;12.42,.39,;11.08,1.16,;11.08,2.7,;9.75,3.47,;8.41,2.7,;7.08,3.47,;7.08,5.01,;5.75,2.7,;4.41,3.47,;4.41,5.01,;3.08,5.78,;5.75,5.78,;5.75,1.16,;4.41,.39,;3.08,1.16,;4.41,-1.16,;3.08,-1.93,;3.08,-3.47,;4.41,-4.24,;4.41,-5.78,;5.75,-3.47,;5.75,-1.93,)|
Structure:
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