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TargetDiacylglycerol kinase gamma
LigandBDBM50239117
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1665293
IC50>50000±n/a nM
Citation Barlaam, BCosulich, SDegorce, SEllston, RFitzek, MGreen, SHancox, ULambert-van der Brempt, CLohmann, JJMaudet, MMorgentin, RPlé, PWard, LWarin, N Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3K?/? inhibitors for the treatment of PTEN-deficient tumours. Bioorg Med Chem Lett27:1949-1954 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol kinase gamma
Name:Diacylglycerol kinase gamma
Synonyms:2.7.1.107 | DAG kinase gamma | DAGK3 | DGK-gamma | DGKG | Diacylglycerol kinase gamma | Diglyceride kinase gamma
Type:PROTEIN
Mol. Mass.:89127.56
Organism:Homo sapiens
Description:ChEMBL_103085
Residue:791
Sequence:
MGEERWVSLTPEEFDQLQKYSEYSSKKIKDALTEFNEGGSLKQYDPHEPISYDVFKLFMR
AYLEVDLPQPLSTHLFLAFSQKPRHETSDHPTEGASNSEANSADTNIQNADNATKADEAC
APDTESNMAEKQAPAEDQVAATPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKL
EFMFRLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFV
SLQEWVHGGMTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGL
CCTYCKYTVHERCVSRNIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQS
VTARHCVWCRMTFHRKCELSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGEL
VMQYKIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFR
DTPDFRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSL
TKILKDIEQSPLVMLDRWHLEVIPREEVENGDQVPYSIMNNYFSIGVDASIAHRFHVMRE
KHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSNIFLEGIAILNI
PSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIY
TGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSSF
FSLRRKSRSKD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50239117
NameBDBM50239117
Synonyms:CHEMBL4060768
TypeSmall organic molecule
Emp. Form.C28H29F2N3O5
Mol. Mass.525.5438
SMILESFc1cc(F)cc(c1)N1CCC[C@@H]1c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N1CCOCC1 |r|
Structure
n/a