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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50240506
Substrate
n/a
Meas. Tech.
ChEMBL_1668291 (CHEMBL4018179)
IC50
13±n/a nM
Citation
 Nambu, M; Covel, JA; Kapoor, M; Li, X; Moloney, MK; Numa, MM; Soltow, QA; Trzoss, M; Webb, P; Webb, RR; Mutz, M A calcineurin antifungal strategy with analogs of FK506. Bioorg Med Chem Lett 27:2465-2471 (2017) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50240506
Synonyms:
CHEMBL4103102
Type:
Small organic molecule
Emp. Form.:
C51H81N3O13
Mol. Mass.:
944.2011
SMILES:
[H][C@]12O[C@](O)([C@H](C)C[C@@H]1OC)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@H]([C@H](C)[C@@H](O)CC(=O)[C@H](\C=C\CCCC(=O)N1CCNCC1)\C=C(C)\C[C@H](C)C[C@@H]2OC)C(\C)=C\[C@@H]1CC[C@@H](O)[C@@H](C1)OC |r,c:50|
Structure:
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