Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Ligand
BDBM50240826
Substrate
n/a
Meas. Tech.
ChEMBL_1668981 (CHEMBL4018869)
Kd
324±n/a nM
Citation
 Zhu, JYCuellar, RABerndt, NLee, HEOlesen, SHMartin, MPJensen, JTGeorg, GISchönbrunn, E Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J Med Chem 60:7863-7875 (2017) [PubMed]  Article 
Target
Name:
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Synonyms:
MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase
Type:
PROTEIN
Mol. Mass.:
54523.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_587209
Residue:
499
Sequence:
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT
  
Inhibitor
Name:
BDBM50240826
Synonyms:
AZD-1775 | MK-1775 | US11124518, Example AZD1775 | US11248006, Compound AZD1775 | US11479555, Example AZD1775
Type:
Small organic molecule
Emp. Form.:
C27H32N8O2
Mol. Mass.:
500.5954
SMILES:
CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)cc1
Structure:
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