Target
Leucine--tRNA ligase, mitochondrial
Ligand
BDBM50241778
Substrate
n/a
Meas. Tech.
ChEMBL_1670427 (CHEMBL4020315)
IC50
>300000±n/a nM
Citation
 Li, XHernandez, VRock, FLChoi, WMak, YSLMohan, MMao, WZhou, YEasom, EEPlattner, JJZou, WPérez-Herrán, EGiordano, IMendoza-Losana, AAlemparte, CRullas, JAngulo-Barturen, ICrouch, SOrtega, FBarros, DAlley, MRK Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem 60:8011-8026 (2017) [PubMed]  Article 
Target
Name:
Leucine--tRNA ligase, mitochondrial
Synonyms:
6.1.1.4 | KIAA0028 | LARS2 | LeuRS | Leucyl-tRNA synthetase | Probable leucine--tRNA ligase, mitochondrial | SYLM_HUMAN
Type:
PROTEIN
Mol. Mass.:
101996.66
Organism:
Homo sapiens
Description:
ChEMBL_117411
Residue:
903
Sequence:
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD
  
Inhibitor
Name:
BDBM50241778
Synonyms:
CHEMBL4086672
Type:
Small organic molecule
Emp. Form.:
C9H12BBrClNO3
Mol. Mass.:
308.364
SMILES:
Cl.COc1ccc(Br)c2[C@@H](CN)OB(O)c12 |r|
Structure:
Search PDB for entries with ligand similarity: