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Target
Acidic mammalian chitinase
Ligand
BDBM50243744
Substrate
n/a
Meas. Tech.
ChEMBL_1672911 (CHEMBL4022940)
IC50
36±n/a nM
Citation
 Mazur, M; Olczak, J; Olejniczak, S; Koralewski, R; Czestkowski, W; Jedrzejczak, A; Golab, J; Dzwonek, K; Dymek, B; Sklepkiewicz, PL; Zagozdzon, A; Noonan, T; Mahboubi, K; Conway, B; Sheeler, R; Beckett, P; Hungerford, WM; Podjarny, A; Mitschler, A; Cousido-Siah, A; Fadel, F; Golebiowski, A Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J Med Chem 61:695-710 (2018) [PubMed]  Article 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | CHIA_MOUSE | Chia | Chia1 | YNL
Type:
PROTEIN
Mol. Mass.:
51991.60
Organism:
Mus musculus
Description:
ChEMBL_828636
Residue:
473
Sequence:
MAKLLLVTGLALLLNAQLGSAYNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
  
Inhibitor
Name:
BDBM50243744
Synonyms:
CHEMBL4098997
Type:
Small organic molecule
Emp. Form.:
C17H25BrN6
Mol. Mass.:
393.325
SMILES:
CCN(CCc1ccc(Br)cc1)C1CCN(CC1)c1nc(N)n[nH]1
Structure:
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