Target
Protein arginine N-methyltransferase 3
Ligand
BDBM50247349
Substrate
n/a
Meas. Tech.
ChEMBL_1677669 (CHEMBL4027812)
IC50
19±n/a nM
Citation
 Kaniskan, HÜEram, MSZhao, KSzewczyk, MMYang, XSchmidt, KLuo, XXiao, SDai, MHe, FZang, ILin, YLi, FDobrovetsky, ESmil, DMin, SJLin-Jones, JSchapira, MAtadja, PLi, EBarsyte-Lovejoy, DArrowsmith, CHBrown, PJLiu, FYu, ZVedadi, MJin, J Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). J Med Chem 61:1204-1217 (2018) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 3
Synonyms:
2.1.1.- | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3
Type:
PROTEIN
Mol. Mass.:
59886.87
Organism:
Homo sapiens
Description:
ChEMBL_101368
Residue:
531
Sequence:
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
  
Inhibitor
Name:
BDBM50247349
Synonyms:
CHEMBL4072005
Type:
Small organic molecule
Emp. Form.:
C16H18N4O2
Mol. Mass.:
298.3397
SMILES:
O=C(NCC(=O)N1CCCC1)Nc1ccc2cnccc2c1
Structure:
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