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Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Ligand
BDBM50247642
Substrate
n/a
Meas. Tech.
ChEMBL_1678430 (CHEMBL4028573)
IC50
3.0±n/a nM
Citation
 Pellicciari, R; Liscio, P; Giacchè, N; De Franco, F; Carotti, A; Robertson, J; Cialabrini, L; Katsyuba, E; Raffaelli, N; Auwerx, J ?-Amino-?-carboxymuconate-?-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD J Med Chem 61:745-759 (2018) [PubMed]  Article 
Target
Name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Synonyms:
ACMSD | ACMSD_HUMAN | Picolinate carboxylase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38037.38
Organism:
Homo sapiens (Human)
Description:
Q8TDX5
Residue:
336
Sequence:
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
  
Inhibitor
Name:
BDBM50247642
Synonyms:
CHEMBL4072240
Type:
Small organic molecule
Emp. Form.:
C17H11N7OS2
Mol. Mass.:
393.446
SMILES:
O=c1[nH]c(SCc2cccc(c2)-c2nnn[nH]2)nc(-c2cccs2)c1C#N
Structure:
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