Reaction Details Report a problem with these data
Target
Advanced glycosylation end product-specific receptor
Ligand
BDBM50249569
Substrate
n/a
Meas. Tech.
ChEMBL_1680057 (CHEMBL4030334)
IC50
<500±n/a nM
Citation
 Bongarzone, S; Savickas, V; Luzi, F; Gee, AD Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective. J Med Chem 60:7213-7232 (2017) [PubMed]  Article 
Target
Name:
Advanced glycosylation end product-specific receptor
Synonyms:
AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products
Type:
PROTEIN
Mol. Mass.:
42800.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1339877
Residue:
404
Sequence:
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
  
Inhibitor
Name:
BDBM50249569
Synonyms:
CHEMBL4063487
Type:
Small organic molecule
Emp. Form.:
C39H53ClN4O4
Mol. Mass.:
677.316
SMILES:
CCCCn1c(nc2cc(OCCCN(CC)CC)ccc12)[C@@H](Cc1ccc(OCCc2ccc(Cl)cc2)cc1)NC(=O)OC(C)(C)C |r|
Structure:
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