Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50469550
Substrate
n/a
Meas. Tech.
ChEMBL_1680060 (CHEMBL4030337)
IC50
19.7±n/a nM
Citation
 Piizzi, GParker, DTPeng, YDobler, MPatnaik, AWattanasin, SLiu, ELenoir, FNunez, JKerrigan, JMcKenney, DOsborne, CYu, DLanieri, LBojkovic, JDzink-Fox, JLilly, MDSprague, ERLu, YWang, HRanjitkar, SXie, LWang, BGlick, MHamann, LGTommasi, RYang, XDean, CR Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC. J Med Chem 60:5002-5014 (2017) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_PSEAE | Protein envA | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-acyl-GlcNAc deacetylase | UDP-3-O-acyl-GlcNAc deacetylase (LpxC) | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33428.15
Organism:
Pseudomonas aeruginosa
Description:
P47205
Residue:
303
Sequence:
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPAAAV
  
Inhibitor
Name:
BDBM50469550
Synonyms:
CHEMBL4070478
Type:
Small organic molecule
Emp. Form.:
C15H19N3O4
Mol. Mass.:
305.3291
SMILES:
CC#CCOc1ccc(cc1)C(=O)N[C@@H]([C@@H](C)N)C(=O)NO |r|
Structure:
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