Target
L-lactate dehydrogenase B chain
Ligand
BDBM50250667
Substrate
n/a
Meas. Tech.
ChEBML_1682055
IC50
75±n/a nM
Citation
 Rai, GBrimacombe, KRMott, BTUrban, DJHu, XYang, SMLee, TDCheff, DMKouznetsova, JBenavides, GAPohida, KKuenstner, EJLuci, DKLukacs, CMDavies, DRDranow, DMZhu, HSulikowski, GMoore, WJStott, GMFlint, AJHall, MDDarley-Usmar, VMNeckers, LMDang, CVWaterson, AGSimeonov, AJadhav, AMaloney, DJ Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem 60:9184-9204 (2017) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase B chain
Synonyms:
L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46
Type:
Oxidoreductase; homotetramer
Mol. Mass.:
36635.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
  
Inhibitor
Name:
BDBM50250667
Synonyms:
CHEMBL4075666 | US10961200, Compound 40 | US11247971, Cmpd ID 40
Type:
Small organic molecule
Emp. Form.:
C26H21N5O4S2
Mol. Mass.:
531.606
SMILES:
Nc1c(Cc2ccc(cc2)S(N)(=O)=O)c(nn1-c1nc(cs1)C(O)=O)-c1cccc(c1)-c1ccccc1
Structure:
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