Reaction Details Report a problem with these data
Target
Glycylpeptide N-tetradecanoyltransferase 1
Ligand
BDBM50364113
Substrate
n/a
Meas. Tech.
ChEBML_1682157
IC50
4.0±n/a nM
Citation
 Bayliss, T; Robinson, DA; Smith, VC; Brand, S; McElroy, SP; Torrie, LS; Mpamhanga, C; Norval, S; Stojanovski, L; Brenk, R; Frearson, JA; Read, KD; Gilbert, IH; Wyatt, PG Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors. J Med Chem 60:9790-9806 (2017) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM50364113
Synonyms:
CHEMBL1230468
Type:
Small organic molecule
Emp. Form.:
C21H24Cl2N6O2S
Mol. Mass.:
495.425
SMILES:
Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: