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Target
Glycylpeptide N-tetradecanoyltransferase 1
Ligand
BDBM50250793
Substrate
n/a
Meas. Tech.
ChEBML_1682157
IC50
40±n/a nM
Citation
 Bayliss, T; Robinson, DA; Smith, VC; Brand, S; McElroy, SP; Torrie, LS; Mpamhanga, C; Norval, S; Stojanovski, L; Brenk, R; Frearson, JA; Read, KD; Gilbert, IH; Wyatt, PG Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors. J Med Chem 60:9790-9806 (2017) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM50250793
Synonyms:
CHEMBL4096886
Type:
Small organic molecule
Emp. Form.:
C24H26Cl2N4O
Mol. Mass.:
457.395
SMILES:
CCCc1ncccc1COc1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Structure:
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