Reaction Details Report a problem with these data
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM50249989
Substrate
n/a
Meas. Tech.
ChEBML_1687628
Kd
8.0±n/a nM
Citation
 Chen, L; Zhuang, C; Lu, J; Jiang, Y; Sheng, C Discovery of Novel KRAS-PDE? Inhibitors by Fragment-Based Drug Design. J Med Chem 61:2604-2610 (2018) [PubMed]  Article 
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Inhibitor
Name:
BDBM50249989
Synonyms:
CHEMBL1387422
Type:
Small organic molecule
Emp. Form.:
C27H31N5O2
Mol. Mass.:
457.5673
SMILES:
CC(CNC(=O)CCCn1nc(C)c2c(C)n(nc2c1=O)-c1ccc(C)cc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: