Target
Metabotropic glutamate receptor 2
Ligand
BDBM50257548
Substrate
n/a
Meas. Tech.
ChEMBL_1689940 (CHEMBL4040510)
Ki
2.2±n/a nM
Citation
 Doornbos, MLJCid, JMHaubrich, JNunes, Avan de Sande, JWVermond, SCMulder-Krieger, TTrabanco, AAAhnaou, ADrinkenburg, WHLavreysen, HHeitman, LHIJzerman, APTresadern, G Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2. J Med Chem 60:6704-6720 (2017) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2
Type:
Enzyme
Mol. Mass.:
95584.88
Organism:
Homo sapiens (Human)
Description:
Q14416
Residue:
872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM50257548
Synonyms:
CHEMBL4104081
Type:
Small organic molecule
Emp. Form.:
C23H24ClF3N4O
Mol. Mass.:
464.911
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F |r,wU:4.7,wD:1.0,(25.74,-27.82,;25.74,-26.28,;27.08,-25.52,;27.09,-23.97,;25.76,-23.21,;24.42,-23.97,;24.41,-25.5,;25.76,-21.67,;27.09,-20.9,;28.43,-21.67,;29.76,-20.9,;29.76,-19.35,;28.42,-18.59,;27.09,-19.36,;25.76,-18.59,;31.08,-18.58,;32.42,-19.35,;33.75,-18.58,;33.75,-17.03,;34.89,-16,;36.4,-16.31,;36.88,-17.77,;36.57,-19.28,;38.03,-18.8,;34.26,-14.59,;32.73,-14.76,;32.41,-16.27,;31.08,-17.04,;29.74,-16.27,;29.74,-14.73,;28.41,-17.05,;28.4,-15.5,)|
Structure:
Search PDB for entries with ligand similarity: