Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM50264416
Substrate
n/a
Meas. Tech.
ChEMBL_1698722 (CHEMBL4049704)
IC50
800±n/a nM
Citation
 Perez, CLi, JParlati, FRouffet, MMa, YMackinnon, ALChou, TFDeshaies, RJCohen, SM Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem 60:1343-1361 (2017) [PubMed]  Article 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM50264416
Synonyms:
CHEMBL4069023
Type:
Small organic molecule
Emp. Form.:
C36H24F6N4O2S2
Mol. Mass.:
722.722
SMILES:
FC(F)(F)c1ccc(CNC(=O)c2cnc3c(SSc4cccc5cc(cnc45)C(=O)NCc4ccc(cc4)C(F)(F)F)cccc3c2)cc1
Structure:
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