Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM50264515
Substrate
n/a
Meas. Tech.
ChEMBL_1698722 (CHEMBL4049704)
IC50
400±n/a nM
Citation
 Perez, CLi, JParlati, FRouffet, MMa, YMackinnon, ALChou, TFDeshaies, RJCohen, SM Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem 60:1343-1361 (2017) [PubMed]  Article 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM50264515
Synonyms:
CHEMBL4070821
Type:
Small organic molecule
Emp. Form.:
C26H16N6O2S4
Mol. Mass.:
572.704
SMILES:
O=C(Nc1nccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)Nc3nccs3)cccc2c1
Structure:
Search PDB for entries with ligand similarity: